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The immune system increases blood flow to the injection site, and this reaction produces warmth, swelling and tenderness that form the earliest symptoms

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Other ions, such as Na + , K + , Cl , and Zn 2+ , are required for lysosomal responses, including transportation, the maintenance of membrane potential, and the activation of lysosomal enzymes 33

The procedure is painless and takes only a couple minutes although the evaluation may take longer

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